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New Technologies for Toxicity Testing

978-1-4614-3054-4
02/07/2012
Balls, Michael
Michael Balls

..• Provides valuable and detailed insight into many of the latest techniques

..• Describes several techniques, which broaden the range and improve the sensitivity and relevance of toxicity endpoints, investigated both in vitro and in vivo

..• Introduces new methods and systems

RAMPs

978-1-4614-2363-8
02/01/2012
Spielman, William S.
William S. Spielman

..• Source of basic studies that range from biochemistry to molecular biology to receptor pharmacology and physiology

..• Written by authors well known in the RAMPs field

..• Provides information for scientists at different stages of their career including graduate students, post-doctoral fellows and senior scientists who are new to the RAMPs field

Caveolins and Caveolae:
Roles in Signaling and Disease Mechanisms

978-1-4614-1221-2
01/30/2012
Jasmin, Jean-François
Jean-François Jasmin

..• Discusses pleiotropic functions of caveolae and caveolin proteins
..• Presents the role and function of caveolae and caveolins in cell signaling and human disease mechanisms
..• Focuses on selected topics

Sensing in Nature

978-1-4614-1703-3
01/30/2012
Lopez-Larrea, Carlos
Carlos Lopez-Larrea

...• Provides a picture of the current state of knowledge of sensory systems in nature
...• Presents an intersection of evolutionary biology, cell and molecular biology, physiology and genetics
...• Written by a distinguished panel of specialists and is intended to be read by biologists, students, scientific investigators and the medical community

..
..Biological systems are an emerging discipline that may provide integrative tools by assembling the hierarchy of interactions among genes, proteins and molecular networks involved in sensory systems. The aim of this volume is to provide a picture, as complete as possible, of the current state of knowledge of sensory systems in nature. The presentation in this book lies at the intersection of evolutionary biology, cell and molecular biology, physiology and genetics. Sensing in Nature is written by a distinguished panel of specialists and is intended to be read by biologists, students, scientific investigators and the medical community.

Self and Nonself

978-1-4614-1679-1
01/24/2012
Lopez-Larrea, Carlos
Carlos Lopez-Larrea

...• Covers different aspects of the emergence of immune systems in the evolution of life
...• Focuses on the origin of the immune response during the development of multicellularity
...• Presents an integrated view of self and nonself recognition systems in the context of evolution

..
..In 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He titled his Nobel Lecture “Immunological Recognition of Self” emphasizing the central argument of immunological tolerance in “How does the vertebrate organism recognize self from nonself in this the immunological sense—and how did the capacity evolve.” The concept of self is linked to the concept of biological self identity. All organisms, from bacteria to higher animals, possess recognition systems to defend themselves from nonself. Even in the context of the limited number of metazoan phyla that have been studied in detail, we can now describe many of the alternative mechanism of immune recognition that have emerged at varying points in phylogeny. Two different arms—the innate and adaptive immune system—have emerged at different moments in evolution, and they are conceptually different. The ultimate goals of immune biology include reconstructing the molecular networks underlying immune processes.

Endocrine FGFs and Klothos

978-1-4614-0886-4
12/22/2011
Kuro-o, Makoto
Makoto Kuro-o

...•Discusses potential of FGF23 and Klotho as novel diagnostic markers and therapeutic targets for chronic kidney disease
...•Gives an overview of current knowledge on FGF19 and FGF21
...•Comprehensive in scope

Notch Signaling in Embryology and Cancer

978-1-4614-0898-7
12/22/2011
Reichrath, Jorg
Jorg Reichrath

...• Comprehensive in scope, covers an overview on our present knowledge of the role of Notch signalling for embryology and cancer, with a focus on new findings in molecular biology
...• Topics are discussed in-depth by leading researchers and clinicians range from the newest findings in cellular and molecular pathology to new concepts for prophylaxis and treatment of cancer
...• Brings the diverse scientific and clinical fields together in one definitive and up-to-date volume

Fuzziness: Structural Disorder in Protein Complexes

978-1-4614-0658-7
12/12/2011
Fuxreiter, Monika
Monika Fuxreiter

..Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.

Neurodegenerative Diseases

978-1-4614-0652-5
11/22/2011
Ahmad, Shamim
Shamim Ahmad

..The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.

Sphingolipids and Metabolic Disease

978-1-4614-0649-5
07/29/2011
Cowart, Ashley
Ashley Cowart

..Current thinking holds that obesity derives primarily from overnutrition (though compelling arguments for other mechanisms, like endocrine disruption by environmental pollutants, also gain support from the literature). In animals, overnutrition is initially handled by adipose tissue expansion; however, exhaustion of this route of lipid sequestering results in oversupply of lipid to other tissues including skeletal muscle, heart, liver, and others. Failure of these tissues to clear excess lipids through either metabolism or sequestration into putatively inert triacylglycerols results in perturbation of bioactive lipid metabolism in cells. In particular, aberrant generation of bioactive sphingolipids is implicated in a multitude of pathological outcomes of metabolic disease including insulin resistance, inflammation, cardiomyopathy, and others. This volume addresses not only the fundamentals of sphingolipid metabolism and analysis, but also the roles of sphingolipids in these disease processes.